Acetic Acid → 1,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone diacetate salt

HRID 1263209Notes

Reaction equation

HRID 1263209 reaction equation
[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1.[C:35]([OH:38])(=[O:37])[CH3:36].C(O)C>CC(C)=O>[C:35]([OH:38])(=[O:37])[CH3:36].[C:35]([OH:38])(=[O:37])[CH3:36].[OH:1][CH:2]([CH3:34])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH:31]([OH:33])[CH3:32])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 702EthanolHCID 4330601,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

Product 1

HCID 867369171,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone diacetate salt

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 60 mg. of glacial acetic acid, and 10 ml. of ethanol is heated on a steam bath for 10 minutes, cooled, treated with 50 ml. of acetone and cooled to obtain the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperaturecooled
  3. additiontreated with 50 ml

Sources & evidence

ORD record
ord-7d8cce6a15a442ecb94e345690fbf78d
Source dataset
uspto-grants-1984_06
Patent number
US04456552

Reaction notes

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