HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-(3-fluoro-2-pyridinyl)-1-piperazinecarboxylate | HCID 20455069 | — |
| Product | Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2) | HCID 20455072 | — |
Reaction Steps
A solution of 1-(3-fluoro-2-pyridinyl)-4-carbethoxy piperazine (700 mg, 2.76 mmol) in 50 ml of 6N hydrochloric acid is stirred at reflux under N2 for 6 hours and then concentrated under reduced pressure. The residue is recrystallized from an ethanol-ethyl acetate mixture to give 1-(3-fluoro-2-pyridinyl) piperazine dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456604 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-cce929f7673d4e6e98b5a386c1bcf1ec |
| Source note | uspto-grants-1984_06 |