反应详情

温度

50 °C

At room temperature, 9.2 g of the compound obtained in step (c) above was dropped into a 55% benzene suspension containing 1.3 g of sodium hydroxide, and the mixture was stirred at 50° C. for 10 minutes. The liquid reaction mixture was cooled to room temperature, and 3.8 g of oxazolyl chloride was dropped into the liquid reaction mixture and the resulting mixture was stirred at 50° C. for 30 minutes. The liquid reaction mixture was filtered and the solvent was removed from the filtrate by distillation under reduced pressure at a temperature lower than 40° C. to obtain 9.5 g of the intended compound in the form of an oil.

1. customThe liquid reaction mixture
2. temperaturewas cooled to room temperature
3. stirringthe resulting mixture was stirred at 50° C. for 30 minutes
4. customThe liquid reaction mixture
5. filtrationwas filtered
6. customthe solvent was removed from the filtrate by distillation under reduced pressure at a temperature lower than 40° C.