Propylene Glycol → HCID 10105638, compound

HRID 1263237Notes

Reaction equation

HRID 1263237 reaction equation
[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:16])/[CH2:10][CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[CH2:3][C:4]#N.[OH-:17].[K+].C(O)C([OH:22])C>O>[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:16])/[CH2:10][CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[CH2:3][C:4]([OH:22])=[O:17]

Participants

5

Reactant 3

HCID 1030Propylene GlycolHCID 14797Potassium HydroxideHCID 20220949HCID 20220949, compound

Product 1

HCID 10105638HCID 10105638, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

To 40 g of the compound obtained in step (b) above were added 35 g of potassium hydroxide, 15 ml of water and 80 ml of propylene glycol, and the mixture was stirred at 130° C. for 7 hours. The extract was washed with water and dried, then the solvent was removed by distillation and then the residue was purified by column chromatography using silica gel to obtain 36 g of the intended compound in the form of an oil.

Workup

  1. washThe extract was washed with water
  2. customdried
  3. customthe solvent was removed by distillation
  4. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-8a240d56c0664885817ccbc560194a69
Source dataset
uspto-grants-1984_06
Patent number
US04456603

Reaction notes

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