HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → HCID 9279521, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloroquinoline | HCID 11928 | — |
| Reactant | p-(1-Piperazinyl)phenol dihydrobromide | HCID 2723591 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | HCID 9279521 | HCID 9279521 | 70% |
Reaction Steps
A mixture of 10.2 parts of 4-(1-piperazinyl)phenol dihydrobromide, 5.7 parts of 2-chloroquinoline, 6.3 parts of potassium carbonate and 80 parts of 1-butanol is stirred and refluxed overnight. The reaction mixture is diluted with water and 2,2'-oxybispropane is added: the product is crystallized. It is filtered off and recrystallized from 4-methyl-2-pentanone, yielding 6.4 parts (70%) of 4-[4-(2-quinolinyl)-1-piperazinyl]phenol; mp. 198.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456605 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-dd63bb84af234e2087557f7370309fbb |
| Source note | uspto-grants-1984_06 |