Hydrazine → HCID 20455093, compound

HRID 1263252Notes

Reaction equation

HRID 1263252 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([NH:15][C:16](=[O:24])OC3C=CC=CC=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[NH2:25][NH2:26]>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([NH:15][C:16]([NH:25][NH2:26])=[O:24])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 54176274HCID 54176274, compound

Product 1

HCID 20455093HCID 20455093, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 8 parts of phenyl [4-(4-methoxyphenyl)-1-piperazinyl]carbamate, 15 parts of hydrazine and 50 parts of 1,4-dioxane is stirred and refluxed for 4 hours. The reaction mixture is evaporated. The residue is triturated in 2-propanol. The product is filtered off and crystallized from 1-butanol, yielding 6.5 parts (84%) of N-[4-(4-methoxyphenyl)-1-piperazinyl]hydrazinecarboxamide.

Workup

  1. temperaturerefluxed for 4 hours
  2. customThe reaction mixture is evaporated
  3. customThe residue is triturated in 2-propanol
  4. filtrationThe product is filtered off
  5. customcrystallized from 1-butanol

Sources & evidence

ORD record
ord-0bc7b895948c42ab951c637d08accf3e
Source dataset
uspto-grants-1984_06
Patent number
US04456605

Reaction notes

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