Acetic Anhydride → HCID 141553735, compound

HRID 1263285Notes

Reaction equation

HRID 1263285 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[Cl:8][C:9]1[C:17]2[O:16][CH:15](/[C:18](=[N:22]\[OH:23])/[O:19][CH2:20][CH3:21])[CH2:14][C:13]=2[CH:12]=[C:11]([C:24](=[O:32])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])[C:10]=1[OH:33]>>[C:1]([O:23]/[N:22]=[C:18](\[CH:15]1[CH2:14][C:13]2[CH:12]=[C:11]([C:24](=[O:32])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[F:31])[C:10]([OH:33])=[C:9]([Cl:8])[C:17]=2[O:16]1)/[O:19][CH2:20][CH3:21])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 141547750HCID 141547750, compound

Product 1

HCID 141553735HCID 141553735, compoundYield 58.4%

Conditions

Temperature
90 °C

Procedure

To acetic anhydride (8 ml.) was added (8h) (400 mg., 1.06 mmole). After stirring for 1 hour at 90° C. the mixture was left to stand at room temperature for 18 hours, then evaporated to dryness under high vacuum. The product, an oil, was triturated in absolute ethanol, giving crystalline (9h), m.p. 111°-112° C. in 58.4% yield. Analysis (C20H17ClFNO6) C,H,N.

Workup

  1. waitwas left
  2. waitto stand at room temperature for 18 hours
  3. customevaporated to dryness under high vacuum
  4. customThe product, an oil, was triturated in absolute ethanol

Sources & evidence

ORD record
ord-cea84b1ca0154d84966cbb0c68c87e39
Source dataset
uspto-grants-1984_06
Patent number
US04456612

Reaction notes

Loading…