Water → HCID 131713566, compound
Reaction equation
[CH3:1][CH2:2][N:3]1[C:9](=[O:10])[C:7](=[O:8])[N:6]([C:11]([NH:13][C@@H:14]([C:22]([NH:24][C@@H:25]2[C:28](=[O:29])[N:27]3[C:30]([C:42]([O-:44])=[O:43])=[C:31]([CH2:34][S:35][C:36]4[N:40]([CH3:41])[N:39]=[N:38][N:37]=4)[CH2:32][S:33][C@H:26]23)=[O:23])[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[O:12])[CH2:5][CH2:4]1.[Na+:45].O>CC(C)=O>[OH2:8].[CH3:17][C:18]([CH3:19])=[O:21].[CH3:1][CH2:2][N:3]1[C:9](=[O:10])[C:7](=[O:8])[N:6]([C:11]([NH:13][C@@H:14]([C:22]([NH:24][C@@H:25]2[C:28](=[O:29])[N:27]3[C:30]([C:42]([O-:44])=[O:43])=[C:31]([CH2:34][S:35][C:36]4[N:40]([CH3:41])[N:39]=[N:38][N:37]=4)[CH2:32][S:33][C@H:26]23)=[O:23])[C:15]2[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=2)=[O:12])[CH2:5][CH2:4]1.[Na+:45]Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Acetone is added to the initial aqueous acetone solution of sodium cefoperazone until the water content is reduced to 14-17% of the acetone volume at a temperature of 5°-25° C., with a preferred temperature range of 18°-25° C., producing a ratio of water/acetone/sodium cefoperazone solution of 1.0-1.5, 7.0-12.0, 1.0 v, v, w. The solution is then stirred until a haze develops, and stirring continued until a thick slurry has formed. Further acetone is then added, with stirring in the aforementioned temperature range until a final water content of 3-5% of the acetone level is obtained. The resulting crystals of sodium cefoperazone can be collected by conventional means, preferably by centrifugation or vacuum filtration, and, if desired washed with available organic solvent, preferably 3% water/acetone solution, then with acetone or ethanol, and dried. The product is preferably dried at about 25°-50° C., preferably under a vacuum of about 0.1 to 10 mm Hg, for about 1 to 20 hours.
Sources & evidence
- ORD record
- ord-6ecf7b9eb39044ada5496f1573a258ee
- Source dataset
- uspto-grants-1984_06
- Patent number
- US04456753
Reaction notes
Loading…