HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitrobenzaldehyde → 4-Fluoro-3-nitrobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitrobenzaldehyde | HCID 85505 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
Reaction Steps
18.6 g (0.1 mol) of 4-chloro-3-nitrobenzaldehyde and 6.4 g (0.11 mol) of potassium fluoride in 50 ml of dimethylformamide are stirred at 160° C. After 3 hours, 4-chloro-3-nitrobenzaldehyde is no longer detectable in the reaction mixture, according to gas chromatography. Instead, 4-fluoro-3-nitrobenzaldehyde has formed quantitatively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456772 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-a4647259a38b44aa9884fa9c225d592e |
| Source note | uspto-grants-1984_06 |