HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(Acetylthio)-1-oxobutyl]-4-hydroxy-4-[(4-methyl)phenyl]-L-proline → 4-hydroxy-4-[(4-methyl)phenyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(Acetylthio)-1-oxobutyl]-4-hydroxy-4-[(4-methyl)phenyl]-L-proline | HCID 22817492 | — |
| Reactant | N-carbobenzyloxy-4-hydroxy-4-[(4-methyl)phenyl]-L-proline | HCID 22817588 | — |
| Product | 4-hydroxy-4-[(4-methyl)phenyl]-L-proline | HCID 22817580 | — |
Reaction Steps
The N-carbobenzyloxy-4-hydroxy-4-[(4-methyl)phenyl]-L-proline form part (a) is hydrogenated according to the procedure of Example 1 (b) to yield 4-hydroxy-4-[(4-methyl)phenyl]-L-proline. This amino acid is then reacted with 4-acetylthiobutyroyl chloride according to the procedure of Example 1 (c) to yield 1-[4-(acetylthio)-1-oxobutyl]-4-hydroxy-4-[(4-methyl)phenyl]-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456761 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-4fb572f65aa34571a11d85aa4fdf495a |
| Source note | uspto-grants-1984_06 |