HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)methyl]-L-prolin → 4-hydroxy-4-[(4-pyridyl)methyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)methyl]-L-prolin | HCID 53928413 | — |
| Reactant | 2-(Acetylthio)-1-oxoethyl-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid | HCID 86738016 | — |
| Product | 4-hydroxy-4-[(4-pyridyl)methyl]-L-proline | HCID 53945117 | — |
Reaction Steps
The N-carbobenzyloxy-4-hydroxy-4-[(4-pyridyl)-methyl]-L-proline from part (a) is hydrogenated according to the procedure of Example 1 (b) to yield 4-hydroxy-4-[(4-pyridyl)methyl]-L-proline. This amino acid is reacted with D-3-acetylthio-2-methylpropionyl chloride according to the procedure of Example 1 (c) to yield [1(S)]-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4-hydroxy-4-[(4-pyridyl)methyl]-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04456761 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-878efcad6e4f4399b654183db627a06a |
| Source note | uspto-grants-1984_06 |