HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 9822381, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Carbonochloridic acid, 4-methoxyphenyl ester | HCID 82128 | — |
| Reactant | 3-(4-Bromo-1-Methyl-1H-Pyrazol-3-Yl)Aniline | HCID 2735391 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 9822381 | HCID 9822381 | 59.7% |
Reaction Steps
To 4-methoxyphenylchloroformate (19 mg, 0.10 mmol) in CH2Cl2 (0.5 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (25 mg, 0.10 mmol) and triethylamine (14 μL, 0.10 mmol) in CH2Cl2 (0.5 mL). The mixture was stirred for 16 h and concentrated. Chromatography on flash silica (40% EtOAc/hexane) gave the title compound as a colourless solid (24 mg, 526), m.p. 140.3-141.8° C. (EtOAc/hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06541209B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-318c4e9e02ea4fdf9942c5ed5ded83c8 |
| Source note | uspto-grants-2003_04 |