Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1263444Generated: November 1, 2026

Isatin → 5H-[1,2,4]Triazino[5,6-b]indole-3-thiol

https://huagongshe.com/reaction/1263444

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsatinHCID 7054—
ReactantThiosemicarbazideHCID 2723789—
Product5H-[1,2,4]Triazino[5,6-b]indole-3-thiolHCID 135403808—

Reaction Steps

In the general synthetic scheme, thiosemicarbazide is reacted with isatin to form 5H-1,2,4-triazino[5,6-b]indole-3(2H)-thione. This product is alkylated with an appropriate halo-derivative to provide the sulfur-substituent desired in the final product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06541472B1
Source datasetuspto-grants-2003_04
ORD IDord-02f572870b44477d8a614b2491090628
Source noteuspto-grants-2003_04