Sodium borohydride → HCID 516469, compound

Participants

Reaction Steps

To an ethanolic solution of 5-ethyl-8-isopropyl-5,10-dihydro-11H-indeno[1,2-b]quinolin-10,11-dione (500 mg, 1,58 mmol) was added sodium borohydride (62 mg, 1.64 mmol) in portions followed by stirring at room temperature for 1 hour. After removing ethanol, the reaction mixture was diluted with water and extracted with chloroform twice. The combined organic layers were washed with saturated sodium chloride solution and dried with sodium sulfate followed by evaporating to remove chloroform. The title compound was obtained by crystallizing the residue from acetone-diethyl ether mixture. 1H-NMR(CDCl3)δ 1.35(6H,d,CH(CH3)2), 1.72(3H,t,NCH2CH3), 3.11(1H,septet,CH), 4.79(2H,q,NCH2), 5.86(1H,s,H-11), 7.52-7.63(3H,m,Ar-H), 7.85(1H,dd,H-9)

Provenance & Evidence