9-Fluorenylmethyl chloroformate → HCID 54202138, compound

Participants

Reaction Steps

9-Fluorenylmethyl chloroformate (6.9 g) was added to biphasic mixture of tert-butyl 4-(4-aminobutyl)benzoate (5.7 g) in THF (100 mL) and saturated aqueous NaHCO3 (50 mL). The resulting mixture was stirred at r.t. for 1 h and then diluted with EtOAc and H2O. The organic layer was separated and washed with brine, dried over MgSO4, filtered and concentrated. The crude material was purified by flash chromatography to give 7.4 g of tert-butyl 4-(4-(9-fluorenylmethoxycarbonyl)-aminobutyl)benzoate.

Provenance & Evidence