HCID 18616992, compound → HCID 135673410, compound

HRID 1263592Notes

Reaction equation

HRID 1263592 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=3[OH:22])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.[OH:23][C:24]1[C:29]([O:30][CH3:31])=[CH:28][C:27]([CH3:32])=[CH:26][C:25]=1B(O)O>>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:10]1[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:25]3[CH:26]=[C:27]([CH3:32])[CH:28]=[C:29]([O:30][CH3:31])[C:24]=3[OH:23])[N:7]=2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 18616992HCID 18616992, compoundHCID 1358542856-Bromo-6'-(2-hydroxy-5-methoxyphenyl)-2,2'-bipyridine

Product 1

HCID 135673410HCID 135673410, compoundYield 43%

Procedure

6-(2-Hydroxy-5-methoxyphenyl)-6′-(2-hydroxy-3-methoxy-5-methylphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-5-methoxyphenyl)-2,2′-bipyridine and 2-hydroxy-3-methoxy-5-methylphenylboronic acid in 43% yield using method F; δH [2H6]-DMSO 13.40,(1H, s), 12.51,(1H, s), 8.37,(1H, d), 8.29,(1H, d), 8.20,(2H, t), 8.14,(2H, d), 7.67,(1H, s), 7.51,(1H, s), 7.00,(1H, d), 6.94,(2H, m), 3.83,(6H, s), 2.34,(3H, s).

Sources & evidence

ORD record
ord-f15e7e61bb9e426e9fc57a541d3ac257
Source dataset
uspto-grants-2003_04
Patent number
US06541490B1

Reaction notes

Loading…