HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 5-Nitro-isophthalic acid 1-(2,5-dioxo-pyrrolidin-1-yl) ester 3-allyl ester | HCID 22986099 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester | HCID 20655861 | — |
Reaction Steps
A mixture of (7(b)) (2.00 g), N,O-dimethylhydroxylamine hydrochloride (0.62 g), triethylamine (0.86 ml) and dichloromethane (60 ml) was stirred at 50 for 30 min and then allowed to warm to ambient temperature and stirred for a further 16 h. The mixture was poured onto a flash column and eluted with ethyl acetate/hexane (40:60) to give 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester (7(c)) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06541491B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-da9fb2defc484709833ce3eac5f1f837 |
| Source note | uspto-grants-2003_04 |