Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-methylhydroxylamine hydrochloride → 3-(N-methyl-hydroxycarbamoyl)-5-nitro-benzoic acid allyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-methylhydroxylamine hydrochloride | HCID 77906 | — |
| 반응물 | 5-Nitro-isophthalic acid 1-(2,5-dioxo-pyrrolidin-1-yl) ester 3-allyl ester | HCID 22986099 | — |
| 반응물 | 3-amino-5(N-methyl-allyloxycarbamoyl)-benzoic acid allyl ester | HCID 22986141 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(N-methyl-hydroxycarbamoyl)-5-nitro-benzoic acid allyl ester | HCID 22986101 | — |
반응 단계
Starting material (8(c)) was prepared as follows. A mixture of 7(b) (2.00 g; see Example 7), N-methylhydroxylamine hydrochloride (1.06 g) triethylamine (1.72 ml) and dichloromethane (60 ml.) was stirred at 5° for 30 minutes. It was then allowed to warm to ambient temperature and stirred for a further 16 hours. The reaction mixture was then poured directly onto a flash column eluting with ethyl acetate/hexane (50:50) to give 3-(N-methyl-hydroxycarbamoyl)-5-nitro-benzoic acid allyl ester (8(a)) as a cream solid (1.43 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06541491B1 |
| 출처 데이터셋 | uspto-grants-2003_04 |
| ORD ID | ord-72f845aa0d474395a02b11627f42fb61 |
| 출처 메모 | uspto-grants-2003_04 |