反应详情

A mixture of (8(b)) (0.523 g), tin(II) chloride dihydrate (1.84 g) and ethyl acetate (50 ml) was heated under reflux for 6 hours. The mixture was allowed to cool to ambient temperature and ammonia solution (sp. g. 0.880) was added dropwise until the solution reached pH 8. The white precipitate which had formed was filtered off. washed with ethyl acetate (2×50 ml) and the combined washings and filtrate evaporated to dryness to give the desired starting material (8(c)) as a yellow oil (0.472 g).

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. customThe white precipitate which had formed
4. filtrationwas filtered off
5. washwashed with ethyl acetate (2×50 ml)
6. customthe combined washings and filtrate evaporated to dryness