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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1263613Generated: October 30, 2026

5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid ethyl ester → 5(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid

https://huagongshe.com/reaction/1263613

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid ethyl esterHCID 22986153—
Reactant5(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid methyl-esterHCID 22986192—
Product5(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acidHCID 1861718482%

Reaction Steps

Compound (13(a)) was treated in an analogous manner to compound (12(a)) in Example 12 to obtain 5(3,4-dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid (13(b)) as an off-white solid (82%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06541491B1
Source datasetuspto-grants-2003_04
ORD IDord-2ca6626a63234688a83ec8c3c1ab8128
Source noteuspto-grants-2003_04