HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → N-(3-methyl-5-isoxazolyl)-4-(4-trifluoromethylphenyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide | HCID 15453181 | — |
| Product | N-(3-methyl-5-isoxazolyl)-4-(4-trifluoromethylphenyl)benzenesulfonamide | HCID 15453184 | 78% |
Reaction Steps
N-(3-methyl-5-isoxazolyl)-4-(4-trifluoromethylphenyl)benzenesulfonamide was prepared in the same manner as described in Example 14b, using N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide and 4-trifluoromethylbenzeneboronic acid resulting in the final product in a 78% yield, m.p. 150-153° C. The product was recrystallized using an acetonirile and water mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06541498B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-1b48915353bc4239845945e082d8cba6 |
| Source note | uspto-grants-2003_04 |