N-bromobutanimide → 4-Bromo-3-(tert-butyl)isoxazol-5-amine

HRID 1263670Notes

Reaction equation

[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([CH3:10])([CH3:9])[CH3:8])[CH:3]=1.[Br:11]N1C(=O)CCC1=O>>[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]=1[Br:11]

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 20956943-Tert-butyl-1,2-oxazol-5-amine

Product 1

HCID 186173124-Bromo-3-(tert-butyl)isoxazol-5-amineYield 64%

Procedure

5-Amino-4-bromo-3-tert-butylisoxazole was prepared from 5-amino-3-tert-butylisoxazole and N-bromosuccinimide in 64% yield as described in Example 25a.

Sources & evidence

ORD record: ord-8a33df0bedab493e9a628e4af6f84ba7
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06541498B2

Reaction notes

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