2,5-Dichlorobenzenesulfonyl chloride → HCID 18617371, compound

HRID 1263699Notes

Reaction equation

HRID 1263699 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:19])=[O:18].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 794012,5-Dichlorobenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617371HCID 18617371, compoundYield 53%

Procedure

2,5-Dichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide 2,5-Dichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,5-dichlorobenzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a yellow powder, m.p. 148-150° C., yield 53%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a yellow powder, m.p. 148-150° C., yield 53%

Sources & evidence

ORD record
ord-e1624b73a2b94edebd2fa43a63202681
Source dataset
uspto-grants-2003_04
Patent number
US06541498B2

Reaction notes

Loading…