(4-Nitrophenyl)acetic acid → 2-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 1263904Notes

Reaction equation

HRID 1263904 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537955052-[(4Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-827311f3ad454d4ab2ab640bc3cd49c1
Source dataset
uspto-grants-2003_04
Patent number
US06541466B2

Reaction notes

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