2-methylpropyl (2S)-2-aminopropanoate → N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

HRID 1263926Notes

Reaction equation

HRID 1263926 reaction equation
[C:1]1([S:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[CH2:13][C:14]([OH:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH2:24])[CH:18]([CH3:20])[CH3:19]>>[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH:24][C:14](=[O:16])[CH2:13][C:12]1[CH:11]=[CH:10][S:9][C:8]=1[S:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 54517004(2-Phenylthiothienyl)acetic acid

Product 1

HCID 53734580N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure BI above, and using (2-phenylthiothienyl)acetic acid and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-cd1ebd497ced415190d0238f062e1cb4
Source dataset
uspto-grants-2003_04
Patent number
US06541466B2

Reaction notes

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