2,5-Difluorophenylacetic acid → N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

HRID 1263929Notes

Reaction equation

HRID 1263929 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 5228232,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 22894969N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

Procedure

Following General Procedure BI above, and using 2,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-2d902196674a4c5aa4fa8c9aebb37bf3
Source dataset
uspto-grants-2003_04
Patent number
US06541466B2

Reaction notes

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