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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264028Generated: October 25, 2026

1-(4-Aminophenyl)-N-methylmethanesulfonamide--hydrogen chloride (1/1) → N-methyl-1-[4-[[5-(1,3-oxazol-5-yl)-2-oxo-1H-indol-3-ylidene]methylamino]phenyl]methanesulfonamide

https://huagongshe.com/reaction/1264028

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Aminophenyl)-N-methylmethanesulfonamide--hydrogen chloride (1/1)HCID 14234262—
ReactantEthoxymethylene-5-oxazol-5-yl-1,3-dihydro-indol-2-oneHCID 53832760—
ProductN-methyl-1-[4-[[5-(1,3-oxazol-5-yl)-2-oxo-1H-indol-3-ylidene]methylamino]phenyl]methanesulfonamideHCID 17848628656%

Reaction Steps

The title compound was prepared in 56% yield from ethoxymethylene-5-oxazol-5-yl-1,3-dihydro-indol-2-one and N-methyl-4-aminophenylmethanesulfonamide hydrochloride according to Procedure J: 1H NMR (DMSO-d6): δ 10.72 (d,1H), 10.67 (s, 1H), 8.71 (d, 1H), 8.37 (s, 1H), 7.43-7.34 (m, 7H), 6.89 (m, 2H), 4.28 (s, 2H), 2.54 (d, 3H); APCI−MS m/z 409 (MH)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06541503B2
Source datasetuspto-grants-2003_04
ORD IDord-3835811d7f994596904ece8278330cdb
Source noteuspto-grants-2003_04