Methyl 4-[4-(tert-Butyldimethylsilyloxy)-2-nitrophenylamino]methyl-2-methoxybenzoate → HCID 12052621, compound

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Reaction Steps

To the above nitro compound (Example 1, Part C; 0.5 g, 1.11 mmol) was added PtO2 (Adam's) catalyst (0.025 g) and EtOH (absolute, 40 mL). The mixture was rapidly stirred under a hydrogen atmosphere (balloon) for 1.5 h and then the catalyst removed by filtering over a pad of diatomaceous earth. The filtrate was concentrated under reduced pressure, yielding 460 mg (99%) of the desired product.

Provenance & Evidence