Hydrochloric Acid → 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride

Participants

Reaction Steps

Methyl 4-[2-(1-pyrrolidinyl)ethoxy]benzoate (5.3 g, 21.2 mol) in 1 N aqueous HCl (50 mL) was heated at reflux for 18 h. The reaction mixture was washed with ethyl acetate (2×20 mL). The aqueous solvent was removed under reduced pressure to give the desired acid as a white solid (5.55 g, 96%) after drying under vacuum at ambient temperature.

Provenance & Evidence