HCID 12052626, compound → HCID 12052627, compound

Participants

Reaction Steps

Adam's catalyst (50 mg, 20% wt.), was added to a degassed solution of N-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]-2-nitroaniline (240 mg, 0.703 mmol) in absolute ethanol (5 mL). The atmosphere was replaced with hydrogen then the reaction was stirred vigorously at ambient temperature until all of the nitro compound had been consumed as determined by tic (9:1 CHCl3:MeOH, 1% TEA). The reaction mixture was filtered through a bed of diatomaceous earth, then the solvent was removed under reduced pressure to give the desired product as a brown yellow oil (218 mg, 100%).

Provenance & Evidence