Potassium Carbonate → HCID 12052631, compound

Participants

Reaction Steps

2-Fluoronitrobenzene (0.358 mL, 3.4 mmol, 1.0 eq.), 3-methoxy-4-[(1-pyrrolidinyl)methyl]benzyl amine (750 mg, 3.4 mmol) and anhydrous potassium carbonate (471 mg, 3.4 mmol, 1.0 eq.) were combined in dry THF (35 mL) then allowed to stir 48 h at ambient temperature. The reaction mixture was filtered through a bed of diatomaceous earth then the solvent was removed under reduced pressure. The crude oil was purified by flash chromatography (eluting with 20:1 CHCl3:MeOH, 0.5% TEA) to give the desired product as a right orange oil (676 mg, 58%).

Provenance & Evidence