4-Ethylbenzoyl chloride → HCID 10131336, compound

HRID 1264105Notes

Reaction equation

HRID 1264105 reaction equation
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1)[CH3:2].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:26])[CH2:20][CH2:21][C:22]([O:24]C)=[O:23])=[CH:15][CH:14]=1>>[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:12][C:13]2[CH:14]=[CH:15][C:16]([C:19](=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[CH:17][CH:18]=2)=[O:8])=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 853684-Ethylbenzoyl chlorideHCID 12016833Methyl 4-(4-aminophenyl)-4-oxobutanoate

Product 1

HCID 10131336HCID 10131336, compoundYield 28.3%

Procedure

In a manner similar to that described in Example 3, 4-ethyl-benzoyl chloride (0.057 g, 0.00034 mol) was allowed to react with 4-(4-amino-phenyl)-4-oxo-butyric acid, methyl ester (0.052 g, 0.00025 mol), and the resulting intermediate was hydrolyzed to give 0.023 g of 4-[4-(4-ethyl-benzoylamino)-phenyl]-4-oxo-butyric acid as an off-white solid; MS-(AP+) MH+326.

Sources & evidence

ORD record
ord-75f01137a0694a98b721c5282fa61fb7
Source dataset
uspto-grants-2003_04
Patent number
US06541521B1

Reaction notes

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