4-Bromobenzoyl chloride → HCID 10292897, compound

HRID 1264108Notes

Reaction equation

HRID 1264108 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:25])[CH2:19][CH2:20][C:21]([O:23]C)=[O:22])=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18](=[O:25])[CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:16][CH:17]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 685154-Bromobenzoyl chlorideHCID 12016833Methyl 4-(4-aminophenyl)-4-oxobutanoate

Product 1

HCID 10292897HCID 10292897, compoundYield 22.3%

Procedure

In a manner similar to that described in Example 3, 4-bromo-benzoyl chloride (0.070 g, 0.00032 mol) was allowed to react with 4-(4-amino-phenyl)-4-oxo-butyric acid, methyl ester (0.052 g, 0.00025 mol), and the resulting intermediate was hydrolyzed to give 0.021 g of 4-[4-(4-bromo-benzoylamino)-phenyl]-4-oxo-butyric acid as a yellow solid; MS-(AP+) MH+376.

Sources & evidence

ORD record
ord-68ba200284dd47bb9157180c6d3ac2d2
Source dataset
uspto-grants-2003_04
Patent number
US06541521B1

Reaction notes

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