3,5-Dimethoxybenzoyl chloride → HCID 10193698, compound

HRID 1264112Notes

Reaction equation

HRID 1264112 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6](Cl)=[O:7].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:28])[CH2:22][CH2:23][C:24]([O:26]C)=[O:25])=[CH:17][CH:16]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6]([NH:14][C:15]1[CH:16]=[CH:17][C:18]([C:21](=[O:28])[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:19][CH:20]=1)=[O:7]

Participants

3

Reactant 2

HCID 870033,5-Dimethoxybenzoyl chlorideHCID 12016833Methyl 4-(4-aminophenyl)-4-oxobutanoate

Product 1

HCID 10193698HCID 10193698, compoundYield 3.4%

Procedure

In a manner similar to that described in Example 3, 3,5-dimethoxy-benzoyl chloride (0.068 g, 0.00034 mol) was allowed to react with 4-(4-amino-phenyl)-4-oxo-butyric acid, methyl ester (0.052 g, 0.00025 mol), and the resulting intermediate was hydrolyzed to give 0.003 g of 4-[4-(3,5-dimethoxy-benzoylamino)-phenyl]-4-oxo-butyric acid as an off-white solid; MS-(AP+) MH+358.

Sources & evidence

ORD record
ord-b6d68296e6724f2ba3cc956cbc7231d7
Source dataset
uspto-grants-2003_04
Patent number
US06541521B1

Reaction notes

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