2-Fluorotoluene → N,N-Dimethyl-3-phenyl-3-(o-tolyloxy)propan-1-amine

HRID 1264195노트

반응식

HRID 1264195 반응식
[H][H].[CH3:3][N:4]([CH2:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[OH:9])[CH3:5].F[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23].CN1CCCC1=O>CN1CCN(C)C1=O>[CH3:3][N:4]([CH2:6][CH2:7][CH:8]([O:9][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:5]

참가 물질

6

반응물 4

HCID 72412-FluorotolueneHCID 13387N-methyl-2-pyrrolidoneHCID 1106653-(Dimethylamino)-1-phenylpropan-1-olHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 12807420N,N-Dimethyl-3-phenyl-3-(o-tolyloxy)propan-1-amine

시약·촉매·용매 1

HCID 66611,3-Dimethyl-2-imidazolidinone용매

실험 절차

In Reaction Scheme B, step a, a nucleophilic aromatic displacement, the alkoxide of an alcohol of formula (1) in which G is methyl or hydrogen, N,N-dimethyl-3-phenyl-3-hydroxypropylamine where G is methyl or N-methyl-3-phenyl-3-hydroxypropylamine where G is hydrogen, is contacted with a 2-fluorotoluene (the compound of formula (2)) in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone to give the compound of formula (3), N,N-dimethyl-3-(2-methylphenoxy)-3-phenylpropylamine, or the compound of formula (4), N-methyl-3-(2-methylphenoxy)-3-phenylpropylamine; respectively.

후처리

  1. customIn Reaction Scheme B, step a, a nucleophilic aromatic displacement

출처 및 근거

ORD 기록
ord-a835ac90fb9446cb9134d09fecdde156
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541668B1

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