Water → [4-[(4-Bromo-2-methylphenyl)ethylamino]-2-chlorophenyl](2-methylphenyl)methanone

Participants

Reaction Steps

A solution of 4-(4-bromo-2-methyl-phenylamino)-2-chloro-2′-methylbenzophenone (Compound 136)(110 mg) in dry tetrahydrofurane (2.0 ml was added sodium hydride (19 mg) in one portion under stirring. After 10 min at room temperature ethyl iodide (124 mg ) was added and the reaction mixture was stirred for 18 hours under reflux, then poured into water and extracted with EtOAc. The organic phases were separated, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by chromatography using a mixture of EtOAc/pentane 1:8 as eluant to yield the title compound as an oil.

Provenance & Evidence