Dimethylformamide → HCID 18617480, compound

Participants

Reaction Steps

To a solution of 2-(4-(furan-2-yl)-phenyl)-2-methyl-propionic Acid (reference example 28) (115 mg, 0.5 mmol) in CH2Cl2 (3 mL) is added DMF (10 mL) followed by oxalyl chloride (0.3 mL, 2M in CH2Cl2). The resulting solution is stirred for 2.5 hours then concentrated. The residue is taken up in methanolic ammonia (7N) and stirred for 14.5 hours, then concentrated to give 124 mg of the title compound as a tan solid. 1H NMR (CDCl3) d 1.58 (s, 6H), 5.2 (bs, 1H), 5.3 (bs, 1H), 6.45 (dd, J=3, 1 Hz, 1H), 6.63 (m, 1H), 7.39 (m, 2H), 7.45 (bs, 1H), 7.65 (m, 2H). MS (EI), m/z 229 (M+).

Provenance & Evidence