Water → HCID 18617628, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-(2-methoxy-pyridin-5-yl)-2-methyl-benzamide (146 mg, 0.35 mmol) (reference example 1n) and pyridinium hydrochloride (3 g) is heated to 160° C. and stirred at this temperature for 3 minutes. The liquid is then cooled and mixed with water. The resulting precipitated solid is filtered, washed with water (3×) then dried under vacuum to give 133 mg of th title compound as a solid. This material is used without further purification. MS (ion spray) m/z 397 (M+H).

Provenance & Evidence