Trifluoroacetic acid → HCID 18617634, compound

Participants

Reaction Steps

To a solution of ethyl 4-(1-tert-butoxycarbonylmethyl-6-oxo-1,6-dihydropyridin-3-yl)benzoate [1.03 g, 2.88 mmol, reference example 85b] in CH2Cl2 [10 ml] and H2O [0.125 ml] is added trifluoroacetic acid [2.5 ml]. After 18 hours removed solvent in vacuo and triturated the resulting solid with methylene chloride to give 0.815 g of the product as a white solid in 93.9% yield. 1H NMR (1:1 CD3OD:CDCl3): δ 1.43 (3H, t, J=7 Hz), 4.40 (2H, q, J=7 Hz), 4.81 (2H, s), 6.73 (1H, d, J=9 Hz), 7.60 (2H, d, J=8 Hz), 7.60 (1H, s), 7.88 (1H, d, J=9.0 Hz), 8.09 (2H, d, J=8 Hz). MS (ion spray) m/z 302 (M+H)+.

Provenance & Evidence