HCID 18617712, compound → HCID 18617722, compound

HRID 1264250Notes

Reaction equation

HRID 1264250 reaction equation
[O:1]=[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)=[N:4][NH:3]1.NC1N=NC=C(C2C=CC(C(OCC)=O)=CC=2)N=1.NC1N=NC(C2C=CC(C(OCC)=O)=CC=2)=CN=1>>[O:1]=[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:17][CH:18]=2)=[N:4][NH:3]1

Participants

4

Reactant 3

HCID 18617712HCID 18617712, compoundHCID 18617785HCID 18617785, compoundHCID 18617855HCID 18617855, compound

Product 1

HCID 18617722HCID 18617722, compound

Procedure

Using the procedure of example 86a except substituting ethyl 4-(3-oxo-2,3-dihydro-[1,2,4]triazin-6-yl)-benzoate (reference example 87b) for a mixture of ethyl 4-(3-amino-[1,2,4]triazin-5-yl)benzoate and ethyl 4-(3-amino-[1,2,4]triazin-6-yl)benzoate afforded the title compound: 1H NMR (DMSO-d6) d 3.90 [(0.2H, d, J=4.9 Hz), (hydrate)], 7.72 (0.80H, s), 8.05 (3.2H, s), 8.11 [(0.4H, d, J=7.7 Hz), (hydrate)], 8.32 [(0.4H, d, J=7.7 Hz), (hydrate)], 8.77 [(0.2H, s), (hydrate)].

Sources & evidence

ORD record
ord-cb9a583ba5a44596a0033cf7664a4cc2
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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