1,2-Ethanediamine, N1,N1-diethyl-N2-methyl- → N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide

HRID 1264258Notes

Reaction equation

HRID 1264258 reaction equation
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][CH2:5][NH:6][CH3:7])[CH3:2].[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:21][CH2:22][NH:23][C:24](=[O:38])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][N:34]=[C:33](Cl)[N:32]=4)=[CH:27][CH:26]=3)[CH:19]=2)[NH:14][CH:13]=1)#[N:11]>>[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:21][CH2:22][NH:23][C:24](=[O:38])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][N:34]=[C:33]([N:6]([CH2:5][CH2:4][N:3]([CH2:8][CH3:9])[CH2:1][CH3:2])[CH3:7])[N:32]=4)=[CH:27][CH:26]=3)[CH:19]=2)[NH:14][CH:13]=1)#[N:11]

Participants

3

Reactant 2

HCID 660341,2-Ethanediamine, N1,N1-diethyl-N2-methyl-HCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 18617504N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide

Procedure

Using 2-(diethylamino)-ethyl-methyl-amine and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates.

Sources & evidence

ORD record
ord-6c1832a07db042808e7923709028180f
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

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