N,N-Diethyl-1,4-butanediamine → N-[2-(3-Cyano-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide

HRID 1264276Notes

Reaction equation

HRID 1264276 reaction equation
[CH2:1]([N:3]([CH2:9][CH3:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8])[CH3:2].[C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][CH2:23][NH:24][C:25](=[O:39])[C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:37]=[CH:36][N:35]=[C:34](Cl)[N:33]=4)=[CH:28][CH:27]=3)[CH:20]=2)[NH:15][CH:14]=1)#[N:12]>>[C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][CH2:23][NH:24][C:25](=[O:39])[C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:37]=[CH:36][N:35]=[C:34]([NH:8][CH2:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:9][CH3:10])[CH2:1][CH3:2])[N:33]=4)=[CH:28][CH:27]=3)[CH:20]=2)[NH:15][CH:14]=1)#[N:12]

Participants

3

Reactant 2

HCID 117976N,N-Diethyl-1,4-butanediamineHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 18617727N-[2-(3-Cyano-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide

Procedure

Using 4-diethylaminobutylamine (reference example 93h) and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. MS (ion spray) m/z 510 (M+H)+.

Sources & evidence

ORD record
ord-503acb00c5884f77aab06a086c1e2ca9
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

Loading…