3-Methoxypropylamine → N-[2-(3-cyano-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide

Participants

Role	Name	HCID	Charge
Reactant	3-Methoxypropylamine	HCID 1672	—
Reactant	N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide	HCID 18617562	—
Product	N-[2-(3-cyano-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide	HCID 18617853	—

Reaction Steps

Using 3-methoxy-propylamine and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. 1H NMR (DMSO) δ 1.81 (m, 2H); 2.98 (m, 2H); 3.24 (s, 3H); 3.41 (m, 4H); 3.56 (m, 2H); 7.19 (m, 2H); 7.28 (bs, 1H); 7.50 (m, 2H); 7.92 (m, 2H); 8.18 (m, 3H); 8.38 (bs, 1H); 8.68 (bs, 1H); 12.13 (bs, 1H). MS (ion spray) m/z 455 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06541505B1
Source dataset	uspto-grants-2003_04
ORD ID	ord-74bd67d67d0d44e28be4b742b71c40d4
Source note	uspto-grants-2003_04