Ethanolamine → HCID 70029433, compound

HRID 1264295Notes

Reaction equation

HRID 1264295 reaction equation
[OH:1][CH2:2][CH2:3][NH2:4].[C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:33])[C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][N:29]=[C:28](Cl)[N:27]=4)=[CH:22][CH:21]=3)[CH:14]=2)[NH:9][CH:8]=1)#[N:6]>>[C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:33])[C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][N:29]=[C:28]([NH:4][CH2:3][CH2:2][OH:1])[N:27]=4)=[CH:22][CH:21]=3)[CH:14]=2)[NH:9][CH:8]=1)#[N:6]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 18617562N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloropyrimidin-4-yl]benzamide

Product 1

HCID 70029433HCID 70029433, compound

Procedure

Using 2-hydroxy-ethylamine and N-[2-(3-Cyano-1H-indol-5-yl)-ethyl]-4-[2-chloro-pyrimidin-4-yl]-benzamide (reference example 1az) as substrates. 1H NMR (DMSO) δ 2.98 (t, 2H, J=7 Hz); 3.44 (bs, 2H); 3.55 (m, 4H); 4.70 (t, 1H, J=6 Hz); 7.17 (m, 3H); 7.48 (m, 2H); 7.92 (d, 2H, J=9 Hz); 8.18 (m, 3H); 8.38 (d, 1H, J=5 Hz); 8.68 (bt, 1H); 12.12 (bs, 1H). MS (ion spray) m/z 427 (M+H)+.

Sources & evidence

ORD record
ord-2af41cf14e2f4073b0820b5dbfb96cdd
Source dataset
uspto-grants-2003_04
Patent number
US06541505B1

Reaction notes

Loading…