Methyl 4-(2-oxo-1,2-dihydropyrimidin-5-yl)benzoate → HCID 54013698, compound

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To a solution of 4-(2-oxo-pyrimidin-5-yl)-benzoic acid methyl ester (761 mg, 3.3 mmol, reference example 19c) in DMF (20 mL) and methanol (5 mL) was added Pd on carbon (250 mg, 10% w/w). The resulting mixtured was stirred under an atmosphere of hydrogen gas for 3 h. This mixture is purged with nitrogen gas then filtered through celite. The filtrate is concentrated and the residue purified by flash chromatography (eluting with 5% methanol in dichloromethane) to give the title compound (421 mg) as a white solid. 1H NMR (CD3OD) ? 3.28 (m, 1H), 3.47 (d, J=7 Hz, 4H), 3.90 (s, 3H), 7.44 (d, J=8 Hz, 2H), 7.90 (d, J=8 Hz, 2H).

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