Water → HCID 18617788, compound

Participants

Reaction Steps

To a solution of (2-[4-[2-(3-cyano-1H-indol-5-yl)-ethylcarbamoyl]-phenyl]-2-methyl-propyl)-carbamic acid tert-butyl ester (1.16 g, 2.5 mmol) (prepared using the procedure of reference example 1w) in CH2Cl2 (8 ml) was added TFA (1.6 ml) and the reaction stirred 2 hrs. Water (50 μL) was add-ed and the reaction concentrated under reduced pressure. The residue was purified by flash chromatography (eluting with 10% 7M NH3 in CH3OH/CH2Cl2) to give 808 mg of product. MS (ion spray) m/z 361 (M+H)+.

Provenance & Evidence