Pyridine → HCID 18617644, compound

Participants

Reaction Steps

To a solution of 4-[2-amino-1,1-dimethyl-ethyl]-N-[2-(3-cyano-1H-indol-5-yl)-ethyl]-benzamide (97 mg, 0.27 mmol) (reference example 105) in CH2Cl2 (1 ml) was added pyridine (24 μL, 0.30 mmol) and methanesulfonyl chloride (23 μL, 0.30 mmol). The reaction was stirred for 5 min then concentrated under reduced pressure. The residue was purified by flash chromatography (eluting with 8% 7M NH3 in CH3OH/CH2Cl2 to give 95 mg of product. MS (ion spray) m/z 439 (M+H)+.

Provenance & Evidence