Trimethylsilyl isocyanate → HCID 18617655, compound

Participants

Reaction Steps

To a solution of 4-[2-amino-1,1-dimethyl-ethyl]-N-[2-(3-cyano-1H-indol-5-yl)-ethyl]-benzamide (90 mg, 0.25 mmol) (reference example 105) in 1,4-dioxane (1 ml) was added trimethylsilyl isocyanate (68 μL, 0.50 mmol). The resulting mixture is stirred for 16 h. The precipitated solids are collected by vacuum filtration, washed with a small volume of CH2Cl2 and dried under high vacuum to give 99 mg of product. MS (ion spray) m/z 404 (M+H)+.

Provenance & Evidence