Hydrochloric Acid → HCID 18617786, compound

Participants

Reaction Steps

To a solution of 4-(2-dimethylamino-pyrimidin-4-yl)-benzoic acid (275 mg, 1.13 mmol reference example 92aab) in H2O (13 ml) was added conc HCl (212 μL, 2.54 mmol) followed by 10% palladium on carbon (366 mg). The resulting mixture was stirred under H2 for 2.5 hrs. The mixture was filtered through a celite pad to remove the catalyst, using CH2Cl2 as a wash. The filtrate was concentrated under reduced pressure to give 260 mg of product as the HCl salt. MS (ion spray) m/z 248 (M+H)+.

Provenance & Evidence