Phenol → 2-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Participants

Reaction Conditions

Reaction Steps

9.3 g (100 mmol) of phenol and 3.9 g (25 mmol) of 75% fluoral hydrate are introduced into a 100 ml reactor. 5.0 g of a catalyst are added and the mixture is heated at 50° C. for 5 hours. The nature of the catalyst employed and the yields of monocondensed products obtained, with their ortho/para ratio, are reported in Table I below.

Provenance & Evidence